Pilot study 2006-2008

The use of the nutraceutical “PROfertil®” - a therapy of the “male factor“, for the improvement of semen quality.

Imhof M., Matthai C., Huber J.C.; presented at EAU Bratislava 2010;

With a rapid increase of abnormal semen analyses in recent years and no established treatment for the improvement of sperm quality available, there is a rising awareness of alternative options approaches such as dietary management with micronutrients.

Is the whole really greater than the sum of its parts?

The aim of this study was to examine a nutrient combination of eight scientifically substantiated individual substances and their impact on sperm quality. The hypothesis was that the effect of all individual substances together would have an additive effect.

Study design

The study collective contains 120 men, on average 35.9 years old (23-58), long-term childlessness (> 2 years) and at least 2 pathologic semen analyses in their anamnesis. Patients with azoospermia, aspermia, varicosis of the testes and urogenital infections were excluded. The patients took 2 capsules of PROfertil® per day for a period of 3 months. After the time period of 3 months a control semen analysis was performed.

Study results

The sperm cell density increased on average from 29.46 million/ml to 53.19 million/ml (+ 80.54%), with an average 23.73 million increase in sperm density per millilitre. The ejaculate volume increased from 2.91 ml to 3.61 ml (+ 24.05%). The number of progressively motile sperm increased from 8.95% to 19.27% (+115.3%) on average. Total motility (excluding static sperm) showed a cumulative increase from 33.13% to 49.27% (+ 48.71%). The number of sperm with normal morphology improved from 31.14% to 38.90% (+24.91%). 30 of 120 subjects achieved a normal sperm count without any abnormalities. 21 pregnancies have been reported.1


  • 30 of 120 subjects achieved a normal sperm count without any abnormalities
  • 21 pregnancies have been reported
  • These results confirm the hypothesis that the combination of individual substances as described in literature shows significantly better results than the sum of the effects of single administration