Support options

Hormone therapy

Where infertility is caused by a hormonal imbalance of the woman hormone therapy (also called fertility drugs) is generally the first step in fertility treatment. There are a number of medications available that aim at regulating irregular periods and triggering ovulation.

Where a man is unable to father a child, the doctor will in some cases initially also recommend treatment with medication. They can help, for instance to improve sperm quality or treat hormonal imbalance.

Artificial insemination (or intrauterine insemination, IUI)

With insemination, the doctor uses a catheter to place washed and concentrated sperm in the uterus, the vagina, the cervix or the fallopian tubes. Insemination is used where sperm quality is fair or where the cervix has been scarred by an infection or inflammation, and where the cervical scar tissue makes it very difficult for the sperm to reach the uterus. Sometimes, it is necessary to use hormones to stimulate the ovaries before insemination.

In vitro fertilization (IVF)

Louise Brown, the world’s first baby to be conceived through IVF (in vitro fertilisation), was born as a healthy baby in 1978. Now, each year thousands of children are conceived by IVF. With IVF, the egg is fertilised outside the body. IVF is usually used, where the egg cannot reach the uterus, because the fallopian tubes have become blocked due to inflammation. IVF can help to conceive, if the woman has uterine fibroids (myoma) or develops antibodies against the sperm, or with insufficient sperm quality, or where the doctor has found no cause for infertility.

Intracytoplasmic sperm injection (ICSI)

With intracytoplasmic sperm injection (ICSI), the doctor injects the sperm directly into the egg. ICSI is used where the sperm cannot fertilise the egg in the woman’s body nor in the test tube and where the women cannot get pregnant despite IVF treatment.

In-vitro maturation (IVM)

In-vitro maturation (IVM) is a new technique, which is not yet a standard option and only offered by a few fertility centres. In IVM, the doctor removes immature eggs from the ovaries of the woman. The eggs then mature in a test tube while exposed to hormones. The further procedure is as with IVF or ICSI.

Surgical sperm retrieval

Sperm retrieval from the epididymis (microsurgical epididymal sperm aspiration, MESA) can help if the vas deferens has become blocked and where it is not possible to surgically unblock it, or where the sperm in the semen sample are immotile (i.e. they cannot move). It can also be used if the male partner cannot ejaculate, for example because he is paraplegic or has had surgery for cancer. Where MESA cannot be performed, some doctors recommend TESE (testicular sperm extraction), Here, the doctor takes sperm from the testicles. MESA and TESE are always performed in conjunction with ICSI.


An operation can help with getting pregnant, if the fallopian tubes are blocked or abdominal adhesions prevent conception. Where the vas deferens has become blocked during hernia surgery, surgeons are sometimes able to unblock it surgically.

Dietary plan as a solution

The exact causes for the occurrence of subfertility are not clear. However, it is believed that the dietary habits and general lifestyle significantly contribute to the extent of the disease.

In 25% to 50% of all subfertile men a specific, pathological reason for the limited sperm analysis cannot be found. The majority of these cases are not related to a hereditary defect, a constitutional disorder or an acquired pathology (e.g. infection). Rather, the pathological sperm analysis is the result of a nutritional supply deficiency, a dysregulation of the energetic and nutritive supply, as well as a mainly nutritive, but also lifestyle-related, impairment of the cell protection, such as oxidative cell stress.

For men suffering from subfertility it is highly recommended to live a healthy lifestyle. Main points to recommend are:

  • Professional and private stress should be reduced, as well as the consumption of drugs, alcohol and nicotine should be avoided, and the consumption of coffee should be reduced to 2 cups or less per day.
  • Obese men should reduce their weight to a healthy level, as overweight is associated with an increase of inflammatory processes and the formation of reactive oxidative substances   and cellular oxidative stress are involved.
  • Excessive heat as in the use of water beds, saunas, hot tubs or wearing tight underwear to occur due to the thermal sensitivity to avoid evolving sperm.
  • Good eating habits to include fresh fruits, leafy vegetables and fish in the diet are favorable.
  • A moderate and regular physical exercise has direct health effects of regular exercise but also indirectly by the reduced stress levels.

However, spermatogenesis is a very complex and biologically complicated procedure that lasts usually for a period of about twelve weeks. During this process the human body needs various essential nutritive substances to support the various developmental stages of the sperm cell, such as vitamins, vitamin-like substances, trace elements, mineral substances and amino acids. These specific nutrients can provide optimal conditions for normal and healthy spermatogenesis.

For normal development of healthy sperm cells, increased nutritional support is possible through consumption of those specific nutrients at levels not achievable through diet modification which may be beneficial for improving the fertility status. It can be demonstrated that with the regular and targeted supply of a balanced combination of specific nutrients in sufficient quantities male fertility may benefit from the nutritional support provided as the natural process of sperm production may be improved on a nutritional basis

Consequently, it is useful and beneficial from a nutritional point of view to meet the special nutritional requirements of those men with poor fertility parameters with dietetic causes by supplementation, in addition to at least a partial modification of the normal diet.

These specific nutrients have a scientifically substantiated positive effect on isolated or several individual stages of the sperm development.

Due to the combinatory and multiplicative effect of the individual micronutrients involved in spermatogenesis as well as under the aspect of the long duration of this specific and complex metabolic process, a useful direct conclusion to single nutrient deficiencies is impossible. The intake of the required essential nutrients in the correct combination and adequate quantity only with the daily food appears therefore, impractical.

For the dietary management of men with fertility disorders PROfertil® is the perfect solution.

As the selection, the requirement and the dosage of the necessary nutrients needed to support male fertility is too complex to be able to be supplied through the daily normal, varied diet, it is recommended for the continuous and balanced supply of these nutrients for the lengthy spermatogenesis to provide them with PROfertil®.

The unique formulation of the individual substances contained in PROfertil® is in line with these scientific results and the specific composition of PROfertil® has been proven in various clinical studies and protected by patents.